Equity Components [Axis]
Common Stock [Member]
Treasury Stock, Common [Member]
Additional Paid-in Capital [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Cash and Cash Equivalents [Axis]
Money Market Funds [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Newsoara License Agreement [Member]
Fair Value Hierarchy and NAV [Axis]
Fair Value, Inputs, Level 1 [Member]
Fair Value, Inputs, Level 2 [Member]
Fair Value, Inputs, Level 3 [Member]
Financial Instrument [Axis]
US Government Agencies Debt Securities [Member]
US Treasury Securities [Member]
Long-Lived Asset, Class [Axis]
Furniture And Office Equipment [Member]
Laboratory Equipment [Member]
Computer Equipment [Member]
Leasehold Improvements [Member]
Manufacturing Equipment [Member]
Construction in Progress [Member]
Geographical [Axis]
Westlake Village [Member]
San Diego [Member]
Research and Development Laboratory [Member]
Manufacturing Space [Member]
Equipment Agreements [Member]
Statistical Measurement [Axis]
Maximum [Member]
Scenario [Axis]
Research And Development Expenses [Member]
General And Administrative Expense [Member]
Plan Name [Axis]
2009 Plan [Member]
2019 Plan [Member]
2022 Plan [Member]
2023 Inducement Plan [Member]
Inducement Plan [Member]
Title and Position [Axis]
Employees Directors and Key Advisers [Member]
2022 Employee Stock Purchase Plan [Member]
Award Type [Axis]
Share-Based Payment Arrangement, Option [Member]
Restricted Stock Units (RSUs) [Member]
Minimum [Member]
Antidilutive Securities [Axis]
Warrant [Member]
Segments [Axis]
Operating Segment [Member]
Cover [Abstract]
Document Type
Amendment Flag
Amendment Description
Document Registration Statement
Document Annual Report
Document Quarterly Report
Document Transition Report
Document Shell Company Report
Document Shell Company Event Date
Document Period Start Date
Document Period End Date
Document Fiscal Period Focus
Document Fiscal Year Focus
Current Fiscal Year End Date
Entity File Number
Entity Registrant Name
Entity Central Index Key
Entity Primary SIC Number
Entity Tax Identification Number
Entity Incorporation, State or Country Code
Entity Address, Address Line One
Entity Address, Address Line Two
Entity Address, Address Line Three
Entity Address, City or Town
Entity Address, State or Province
Entity Address, Country
Entity Address, Postal Zip Code
Country Region
City Area Code
Local Phone Number
Extension
Written Communications
Soliciting Material
Pre-commencement Tender Offer
Pre-commencement Issuer Tender Offer
Title of 12(b) Security
No Trading Symbol Flag
Trading Symbol
Security Exchange Name
Title of 12(g) Security
Security Reporting Obligation
Annual Information Form
Audited Annual Financial Statements
Entity Well-known Seasoned Issuer
Entity Voluntary Filers
Entity Current Reporting Status
Entity Interactive Data Current
Entity Filer Category
Entity Small Business
Entity Emerging Growth Company
Elected Not To Use the Extended Transition Period
Document Accounting Standard
Other Reporting Standard Item Number
Entity Shell Company
Entity Public Float
Entity Bankruptcy Proceedings, Reporting Current
Entity Common Stock, Shares Outstanding
Documents Incorporated by Reference [Text Block]
Statement of Financial Position [Abstract]
ASSETS
Current assets:
Cash, cash equivalents and restricted cash
Marketable securities
Prepaid expenses and other current assets
Total current assets
Property and equipment, net
Right of use assets
Other assets
Total Assets
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable and accrued expenses
Accrued payroll and payroll taxes
Lease liabilities, current portion
Total current liabilities
Lease liabilities, long-term portion
Total liabilities
Commitments and contingencies (Note 8)
Stockholders’ equity:
Common stock, par value $0.001, 200,000,000 shares authorized; 44,840,416 and 38,139,144 shares issued and outstanding, respectively
Treasury stock, 433,333 shares, at cost
Additional paid-in capital
Accumulated other comprehensive income
Accumulated deficit
Total stockholders’ equity
Total Liabilities and Stockholders’ Equity
Common stock, par value
Common stock, shares authorized
Common stock, shares issued
Common stock, shares outstanding
Treasury stock, shares
Income Statement [Abstract]
Revenue
Operating expenses:
Research and development
General and administrative
Total operating expenses
Operating loss
Other income:
Interest income
Bond accretion income
Total other income
Net loss
Net loss per share - basic
Net loss per share - diluted
Weighted-average shares outstanding- basic
Weighted-average shares outstanding- diluted
Other comprehensive loss:
Unrealized loss on marketable securities
Comprehensive loss
Statement [Table]
Statement [Line Items]
Balance
Balance, shares
Treasury stock balance, shares
Stock compensation
Unrealized loss on marketable securities
Fair value of vested restricted stock units
Fair value of vested restricted stock units , shares
Cost of stock option repricing
Issuance of common stock for cash
Issuance of common stock for cash, shares
Issuance of common stock upon exercise of stock options
Issuance of common stock upon exercise of stock options, shares
Net loss
Balance
Balance, shares
Treasury stock balance, shares
Statement of Cash Flows [Abstract]
Cash Flows from operating activities
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation expense
Net amortization of premiums and discounts on marketable securities
Right-of-use asset
Stock compensation
Fair value of restricted stock units
Cost of stock option modifications and repricing
Changes in operating assets and liabilities:
Prepaid expenses and other assets
Accounts payable and accrued expenses
Accrued payroll and payroll taxes
Lease liability
Net cash used in operating activities
Cash Flows from investing activities
Purchases of property and equipment
Purchase of marketable securities
Proceeds from maturities of marketable securities
Net cash (used in) provided by investing activities
Cash Flows from financing activities
Proceeds from the exercise of stock options
Proceeds from common stock issued
Net cash provided by financing activities
Net increase in cash, cash equivalents and restricted cash
Cash, cash equivalents and restricted cash
BEGINNING OF PERIOD
END OF PERIOD
Supplemental non-cash financing disclosures:
Unrealized loss on marketable securities
Remeasurement of right of use asset and lease liability upon lease extension
Pay vs Performance Disclosure [Table]
Executive Category [Axis]
Individual [Axis]
Adjustment to Compensation [Axis]
Measure [Axis]
Pay vs Performance Disclosure, Table
Company Selected Measure Name
Named Executive Officers, Footnote
Peer Group Issuers, Footnote
Changed Peer Group, Footnote
PEO Total Compensation Amount
PEO Actually Paid Compensation Amount
Adjustment To PEO Compensation, Footnote
Non-PEO NEO Average Total Compensation Amount
Non-PEO NEO Average Compensation Actually Paid Amount
Adjustment to Non-PEO NEO Compensation Footnote
Equity Valuation Assumption Difference, Footnote
Compensation Actually Paid vs. Total Shareholder Return
Compensation Actually Paid vs. Net Income
Compensation Actually Paid vs. Company Selected Measure
Total Shareholder Return Vs Peer Group
Compensation Actually Paid vs. Other Measure
Tabular List, Table
Total Shareholder Return Amount
Peer Group Total Shareholder Return Amount
Net Income (Loss)
Company Selected Measure Amount
Other Performance Measure, Amount
Adjustment to Compensation, Amount
PEO Name
Name
Non-GAAP Measure Description
Additional 402(v) Disclosure
Pension Benefits Adjustments, Footnote
Equity Awards Adjustments, Footnote
Erroneously Awarded Compensation Recovery [Table]
Restatement Determination Date [Axis]
Restatement Determination Date
Aggregate Erroneous Compensation Amount
Erroneous Compensation Analysis
Stock Price or TSR Estimation Method
Outstanding Aggregate Erroneous Compensation Amount
Aggregate Erroneous Compensation Not Yet Determined
Name
Forgone Recovery due to Expense of Enforcement, Amount
Forgone Recovery due to Violation of Home Country Law, Amount
Forgone Recovery due to Disqualification of Tax Benefits, Amount
Forgone Recovery, Explanation of Impracticability
Name
Compensation Amount
Restatement does not require Recovery
Awards Close in Time to MNPI Disclosures [Table]
Award Timing MNPI Disclosure
Award Timing Method
Award Timing Predetermined
Award Timing MNPI Considered
Award Timing, How MNPI Considered
MNPI Disclosure Timed for Compensation Value
Awards Close in Time to MNPI Disclosures, Table
Name
Underlying Securities
Exercise Price
Fair Value as of Grant Date
Underlying Security Market Price Change
Trading Arrangements, by Individual [Table]
Trading Arrangement [Axis]
Material Terms of Trading Arrangement
Name
Title
Rule 10b5-1 Arrangement Adopted
Non-Rule 10b5-1 Arrangement Adopted
Adoption Date
Rule 10b5-1 Arrangement Terminated
Non-Rule 10b5-1 Arrangement Terminated
Termination Date
Expiration Date
Arrangement Duration
Aggregate Available
Insider Trading Policies and Procedures [Line Items]
Insider Trading Policies and Procedures Adopted
Insider Trading Policies and Procedures Not Adopted
Organization, Consolidation and Presentation of Financial Statements [Abstract]
BASIS OF PRESENTATION
Accounting Policies [Abstract]
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES
License Agreements
LICENSE AGREEMENTS
Fair Value Disclosures [Abstract]
FAIR VALUE MEASUREMENTS
Investments, All Other Investments [Abstract]
INVESTMENTS
Balance Sheet Accounts
BALANCE SHEET ACCOUNTS
Leases
LEASES
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES
Equity [Abstract]
STOCKHOLDERS’ EQUITY
Share-Based Payment Arrangement [Abstract]
STOCK BASED COMPENSATION
Earnings Per Share [Abstract]
NET LOSS PER SHARE
Segment Reporting [Abstract]
SEGMENT INFORMATION
Cash Equivalents and Restricted Cash
Marketable Securities
Comprehensive Loss
Recent Accounting Pronouncements
SCHEDULE OF FINANCIAL ASSETS AND LIABILITIES MEASURED AT FAIR VALUE ON A RECURRING BASIS
SCHEDULE OF AVAILABLE FOR SALE INVESTMENTS
SCHEDULE OF PROPERTY AND EQUIPMENT
SCHEDULE OF ACCRUED EXPENSE
SCHEDULE OF COMPONENTS OF LEASE ASSETS AND LIABILITIES
SCHEDULE OF LEASE COST
SCHEDULE OF MATURITIES LEASE LIABILITIES
SCHEDULE OF PREFERRED STOCK AND COMMON STOCK
SCHEDULE OF AWARDS OUTSTANDING
SCHEDULE OF STOCK-BASED COMPENSATION EXPENSES
SCHEDULE OF RESTRICTED STOCK UNITS ACTIVITY
SCHEDULE OF ASSUMPTIONS USED FOR OPTIONS GRANTED
SCHEDULE OF STOCK OPTION ACTIVITY
SCHEDULE OF WARRANTS ACTIVITIES
SCHEDULE OF POTENTIALLY DILUTIVE SECURITIES
SCHEDULE OF SEGMENT INFORMATION
Net loss
Cash used in operations
Cash, cash equivalents and restricted cash
Rrestricted cash
Short-term investments
Cash and Cash Equivalent [Table]
Cash and Cash Equivalents [Line Items]
Cash equivalents
Restricted cash
Unrealized gains on short term investments, net of tax
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront and milestone payment
Upfront payment
Milestone payment
Additional development and commercial milestone payments
Fair Value, off-Balance-Sheet Risk [Table]
Fair Value, off-Balance-Sheet Risks, Disclosure Information [Line Items]
Money market funds
Total financial assets
Debt Securities, Held-to-Maturity, Allowance for Credit Loss [Table]
Debt Securities, Held-to-Maturity, Allowance for Credit Loss [Line Items]
Amortized Cost
Gross Unrealized Gains
Gross Unrealized Losses
Fair Value
Property, Plant, and Equipment [Table]
Property, Plant, and Equipment [Line Items]
Total gross carrying amount
Less: accumulated depreciation and amortization
Property and equipment, net
Schedule Of Accrued Expense
Accrued research and development expenses
Accrued personnel-related expenses
Other
Total accrued expenses
LeasesTable [Table]
Area of land
Lease expires
Option to extend lease
Lease description
Lease term amount
Lease payments
Security deposit
Schedule Of Components Of Lease Assets And Liabilities
Operating lease assets
Current operating lease liabilities
Non-current operating lease liabilities
LeasesCostTable [Table]
Lease cost
Schedule Of Maturities Lease Liabilities
2026 (remainder)
2027
2028
2029
2030
Thereafter
Total
Less imputed interest
Total operating lease liabilities (include current portion)
Preferred stock, par value
Preferred stock, shares authorized
Preferred stock, shares issued
Preferred stock, shares outstanding
Accumulated Other Comprehensive Income (Loss) [Table]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Number of shares issued
Offering price per share
Net proceeds from offering
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Total awards outstanding
Stock-based compensation expenses
Number of restricted shares, beginning
Weighted average grant date fair value, beginning
Number of restricted shares, granted
Weighted average grant date fair value, granted
Number of restricted shares, vested
Weighted average grant date fair value, vested
Number of restricted shares, forfeited
Weighted average grant date fair value, forfeited
Number of restricted shares, ending
Weighted average grant date fair value, ending
Exercise price
Expected dividend yield
Expected volatility
Risk free interest rate, minimum
Expected term of options
Number of options shares, beginning
Weighted average exercise price (per share), beginning
Weighted average remaining contractual terms (in years), outstanding
Number of options shares, granted
Weighted average exercise price (per share), granted
Number of options shares, cancelled
Weighted average exercise price (per share), cancelled
Number of options shares, exercised
Weighted average exercise price (per share), exercised
Number of options shares, expired
Weighted average exercise price (per share), expired
Number of options shares, ending
Weighted average exercise price (per share), ending
Aggregate intrinsic value, ending
Number of options shares, vested and exercisable
Weighted average exercise price (per share), vested and exercisable
Weighted average remaining contractual terms (in years), vested and exercisable
Aggregate intrinsic value, vested and exercisable
Number of options shares, unvested
Number of warrant shares, beginning
Exercise price range range per share, beginning
Weighted average exercise price, beginning
Number of warrant shares, granted
Exercise price range per share, granted
Weighted average exercise price, granted
Number of warrant shares, cancelled
Exercise price range per share, cancelled
Weighted average exercise price, cancelled
Number of warrant shares, exercised
Exercise price range per share, exercised
Weighted average exercise price, exercised
Number of warrant shares, expired
Exercise price range per share, expired
Weighted average exercise price, expired
Number of warrant shares, ending
Exercise price range per share, ending
Weighted average exercise price, ending
Number of warrant shares, vested and exercisable
Exercise price range per share, vested and exercisable
Weighted average exercise price, vested and exercisable
Number of shares granted
Shares of common stock issued
Common stock outstanding percentage
Number of shares available for grant
Number of shares, issued
Unamortized stock compensation expense
Fair market value of shares percentage, description
Exercise price per share
Exercise price per share
Repricing costs
Exercise price range, lower range limit
Exercise price range, upper range limit
Weighted average exercise price
Unvested stock option expense
Intrinsic value for warrant shares outstanding
Employee stock purchase plan description
Employee stock purchase, shares
Authorized and available, shares
Antidilutive Security, Excluded EPS Calculation [Table]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total
Segment Reporting [Table]
Segment Reporting [Line Items]
Research and development, excluding salaries
Salaries
Insurance
Stock-based compensation
Operating expenses
Operating loss
Other income
Number of segments
Bond accretion income.
Adjustments to additional paid in capital cost of stock option modification and repricing.
Fair value of restricted stock units.
Cost of stock option modifications repricing.
Remeasurement of right of use asset and lease liability upon lease extension.
License Agreements [Text Block]
Milestone payment.
Newsoara License Agreement [Member]
Upfront payment.
Upfront and milestone payment.
Additional development and commercial milestone payments.
Balance Sheet Accounts Disclosure [Text Block]
Manufacturing Equipment [Member]
Accrued research and development expenses
Westlake Village [Member]
San Diego [Member]
Research and Development Laboratory [Member]
Manufacturing Space [Member]
Equipment Agreements [Member]
Schedule of Components of Lease Assets and Liabilities [Table Text Block]
Lessee operating lease liability payments due after year four.
2009 Plan [Member]
2019 Plan [Member]
2022 Plan [Member]
Number of shares of common stock percentage.
2023 Inducement Plan [Member]
Share based compensation arrangement by share based payment awards outstanding number.
Inducement Plan [Member]
Fair market value of shares percentage, description.
Repricing costs.
Employees Directors and Key Advisers [Member]
Share based compensation arrangement by share based payment award nonoption equity instruments exercisable number.
Share based compensation arrangement by share based payment award nonoption equity instruments outstanding exercise price range.
Share based compensation arrangement by share based payment award nonoption equity instruments granted exercise price range.
Share based compensation arrangement by share based payment award nonoption equity instruments forfeited exercise price range.
Share based compensation arrangement by share based payment award nonoption equity instruments exercised exercise price range.
Share based compensation arrangement by share based payment award nonoption equity instruments expired exercise price range.
Share based compensation arrangement by share based payment award nonoption equity instruments exercisable exercise price range.
Share based compensation arrangement by share based payment award nonoption equity instruments outstanding weighted average exercise price.
Share based compensation arrangement by share based payment award nonoption equity instruments exercisable weighted average exercise price.
Share based compensation arrangement by share based payment award nonoption equity instruments expired weighted average exercise price.
Share based compensation arrangement by share based payment award nonoption equity instruments exercised weighted average exercise price.
Share based compensation arrangement by share based payment award nonoption equity instruments issued weighted average exercise price.
Share based compensation arrangement by share based payment award nonoption equity instruments forfeited weighted average exercise price.
Share based compensation arrangement by share based payment award non options outstanding intrinsic value.
Employee stock purchase plan description.
2022 Employee Stock Purchase Plan [Member]
Operating Segment [Member]
Research and development excluding salaries.
Furniture And Office Equipment [Member]
Laboratory Equipment [Member]
General And Administrative Expense [Member]
Research And Development Expenses [Member]
Unrealized loss on marketable securities.
Assets, Current
Assets
Liabilities, Current
Liabilities
Treasury Stock, Value
Equity, Attributable to Parent
Liabilities and Equity
Nonoperating Income (Expense)
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Shares, Outstanding
OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax
Accretion (Amortization) of Discounts and Premiums, Investments
Share-Based Payment Arrangement, Noncash Expense
CostOfStockOptionModificationsRepricing
Increase (Decrease) in Prepaid Expense and Other Assets
Increase (Decrease) in Accounts Payable and Accrued Liabilities
Increase (Decrease) in Accrued Taxes Payable
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Payments to Acquire Property, Plant, and Equipment
Payments to Acquire Investments
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
UnrealizedLossOnMarketableSecurities
Forgone Recovery, Individual Name
Outstanding Recovery, Individual Name
Awards Close in Time to MNPI Disclosures, Individual Name
Trading Arrangement, Individual Name
Restricted Cash and Cash Equivalent, Current
Debt Securities, Available-for-Sale, Unrealized Loss
Property, Plant, and Equipment, Accumulated Depreciation, Depletion, and Amortization
Accrued Liabilities
Lessee, Operating Lease, Liability, to be Paid
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Expirations in Period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Nonvested, Number of Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingExercisePriceRange
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Forfeitures
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Exercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Expirations
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableNumber
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableExercisePriceRange
ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsExercisableWeightedAverageExercisePrice